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jaundice in neonates medical preview

we will talk about jaundice in neonates in a medical preview

Jaundice is the most common condition
 that requires medical attention in newborns.
 The yellow coloration of the skin and sclera
in newborns with jaundice is the result of accumulation
of unconjugated bilirubin. In most infants, unconjugated
 hyperbilirubinemia reflects a normal transitional
 phenomenon. However, in some infants, serum
bilirubin levels may rise excessively, which can
 be cause for concern because unconjugated bilirubin

is neurotoxic and can cause death in newborns
 and lifelong neurologic sequelae in infants who
survive (kernicterus). For these reasons, the presence
 of neonatal jaundice frequently results in diagnostic evaluation.
Neonatal jaundice may have first been described in a Chinese textbook 1000 years ago. Medical theses, essays, and textbooks from the 18th and 19th centuries contain discussions about the causes and treatment of neonatal jaundice. Several of these texts also describe a lethal course in infants who probably had Rh isoimmunization. In 1875, Orth first described yellow staining of the brain, in a pattern later referred to by Schmorl as kernicterus.