we will describe the active substance miconazole nitrate and its side effects
Miconazole, sold under the brand name Monistat among others, is a antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina.
It is applied to the skin or vagina as a cream or ointment.
Common side effects include itchiness or irritation of the area in which it was applied.
Use in pregnancy is believed to be safe for the baby.
Miconazole is in the imidazole family of medications. It works by decreasing the ability of fungi to make ergosterol, an important part its cell membrane.
Miconazole was patented in 1968 and approved for medical use in 1971. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. The wholesale cost in the developing world is about 0.23 to 0.60 USD for a 30 gm tube.
In the United States a course of treatment costs less than 25 USD.
Miconazole is mainly used externally for the treatment of athlete's foot, ringworm, and jock itch. Internal application is used for oral or vaginal thrush (yeast infection). The oral gel may also be used for the lip disorder angular cheilitis.
In the UK, miconazole may be used to treat neonatal oral thrush, while the alternative nystatin is only licensed for patients over the age of one month, but drug interactions are possible.
Unlike nystatin, some miconazole is absorbed by the intestinal tract when used orally (and possibly if used vaginally
); this may lead to drug interactions.
Interactions are possible with anticoagulants, phenytoin, terbinafine,, some newer atypical antipsychotics, cyclosporin, and some statins used to treat hypercholesterolemia.